Antibiotics for Sinus Infection: What You Need to Know

If you’ve ever had a sinus infection, you know the pressure, the congestion, and the urge to take something strong. But not every sinus infection needs antibiotics. Most are caused by viruses, and they get better on their own with rest, fluids, and a little over‑the‑counter help. Knowing when antibiotics actually help can save you from unnecessary side effects and keep bacteria from getting resistant.

When antibiotics are actually needed

Doctors usually prescribe antibiotics only if the infection lasts longer than 10 days, gets worse after a few days, or comes with a high fever. These signs suggest a bacterial infection rather than a viral one. If you have a sudden spike in facial pain, thick green or yellow discharge, and you’ve already tried decongestants and saline rinses without relief, it’s time to call a professional.

Even then, the doctor might wait a day or two to see if symptoms improve before reaching for a prescription. This “watchful waiting” approach works for many people and avoids unnecessary drug use.

Common antibiotics and how to use them

The most common antibiotics for sinus infection are amoxicillin, amoxicillin‑clavulanate (Augmentin), doxycycline, and a few newer options like levofloxacin if you’re allergic to penicillin. Amoxicillin is usually taken three times a day for 7‑10 days. Make sure you finish the whole course, even if you start feeling better after a few days.

Side effects can include stomach upset, diarrhea, or a rash. Taking the medicine with food can help with stomach issues. If you notice severe diarrhea, contact your doctor right away—sometimes a probiotic can keep the good bacteria in balance.

Doxycycline is taken once or twice a day and works well for people who can’t take penicillin. It can make you sensitive to sunlight, so wear a hat or sunscreen if you’re outside a lot.

Never share antibiotics with anyone else, and never use leftover pills for a new infection. Each infection is different, and the wrong drug can do more harm than good.

Besides antibiotics, treatments that help clear the sinuses are key. Saline nasal sprays, steam inhalation, and nasal steroid sprays reduce swelling and let the mucus drain. Over‑the‑counter pain relievers like ibuprofen or acetaminophen help with the ache while you recover.

If you’re worried about antibiotic resistance or side effects, ask your doctor about a short course or a different class of drug. Some doctors use a “high‑dose amoxicillin” strategy to beat resistant bacteria without resorting to stronger, broader antibiotics.

In short, antibiotics are a tool, not a cure‑all. Use them when a doctor says they’re needed, follow the dosing instructions, and pair them with supportive care. That way you’ll get relief faster and keep your body’s natural defenses strong.